Past Solicitations
BAA 15DHS-001
National Bio- and Agrodefense Facility Transition Research Project

This solicitation is a Broad Agency Announcement (BAA) as contemplated in Federal Acquisition Regulation (FAR) 6.102(d)(2) and 35.016 to provide for competitive selection of research proposals. A formal Request for Proposals (RFP), solicitation or additional information regarding this announcement will not be issued. This BAA is issued by the Department of the Interior, Interior Business Center (DOI/IBC), Acquisition Services Directorate on behalf of the Department of Homeland Security (DHS) Science & Technology (S&T) Directorate. DOI/IBC will not issue paper copies of this announcement. Technical and cost proposals (or any other material) submitted in response to this BAA will not be returned. All proposals will be treated as sensitive competitive information and their contents will be disclosed only for the purpose of evaluation. DOI/IBC reserves the right to select for award and fund all, some, or none of the Full Proposals received in response to this solicitation. No funding for direct reimbursement of proposal development costs will be allowed. Technical and cost proposals (or any other material) submitted in response to this BAA will not be returned. However, depending on the markings on the proposal, DOI/IBC will adhere to FAR policy on handling source selection information and proprietary proposals. It is the policy of DOI/IBC to treat all proposals as sensitive competitive information and to disclose their contents only for the purposes of evaluation.

Topics

TTA-1 - EVALUATION OF CONTROL AND ERADICATION TOOLS OR METHODS THAT CAN BE INCORPORATED INTO STRATEGIES TO ADDRESS EMERGING AND TRANSBOUNDARY ANIMAL DISEASES

Novel approaches to this issue should look beyond traditional countermeasures to evaluate control and eradication strategies for emerging and transboundary animal diseases. Areas of interest for the NBAF include an analysis of comparative immunology and host pathogen interactions that will enhance understanding of the mechanisms by which pathogens invade and infect host animals and the mechanisms hosts use to defend against pathogens. Research related to host-pathogen interactions is also expected to yield better understanding of the mechanisms of innate immunity. The presence of innate defense systems in a wide variety of organisms, combined with the possibility of identifying additional evolutionarily conserved elements of these systems, presents an important research opportunity to improve our understanding of the common mechanisms and principles of innate immune defenses. Overall, these studies will yield needed mechanistic understanding of host-pathogen dynamics which will in turn improve our understanding of animal resilience to pathogens through breeding or with rationally designed biotherapeutics and new knowledge that will be useful for the development of novel monitoring and surveillance technologies. Identification of genetic variants and common pathways involved in pathogenesis and host responses could be used to predict future disease outbreaks and design disease countermeasures including new diagnostic and vaccine targets for transboundary animal diseases as well as a better understanding of genetic resistance or susceptibility to disease. Specific focus on both the animal and human components of zoonotic disease is also of interest. For details, please refer to the solicitation details located at FedBizOpps website.

TTA-2 - NOVEL SCREENING, SURVEILLANCE, AND DIAGNOSTIC TOOL DEVELOPMENT

Novel technologies for screening, surveillance, and diagnostics are needed to more rapidly identify infected animals, facilitate surveillance of non-infected animals during an outbreak, and facilitate proof of freedom from disease post outbreak. These technologies should be rapid, highly sensitive and specific, and be rapidly deployable in an emergency situation. Technologies at a TRL of 5 or higher (see Appendix C) should meet or exceed the minimum requirements for pathogen detection and commonly available commercial-off-the-shelf COTS technologies. Technologies with TRL below 5 should clearly outline how the technology differs from what is currently available and present a path forward for developing the technology to a TRL 6 -7 for prototyping. For details, please refer to the solicitation details located at FedBizOpps website.

TTA-3 - MODELS, TOOLS, OR METHODS TO ASSESS EPIDEMIOLOGICAL, SOCIAL, AND ECONOMIC IMPACTS OF NEXT-GENERATION VACCINES AND COUNTERMEASURES

Several models have been used to evaluate the effects of a TAD outbreak on animal populations and the livestock industry; however, some of these models, methods, and tools have been developed using data from the 2001 FMD outbreak in the U.K. The confidence of these data to accurately assess the impact of an FMD outbreak in the United States is lacking. New models, tools, or methods for evaluating the epidemiologic, social, and economic impact of a TAD introduction to the United States are necessary in order to accurately quantify the consequences of an introduction and evaluate the effectiveness of existing, new, and enhanced countermeasures and next-generation vaccines. For details, please refer to the solicitation details located at FedBizOpps website.

TTA-4 - NOVEL APPROACHES TO VACCINE PLATFORM DEVELOPMENT FOR EMERGING, ZOONOTIC, AND TRANSBOUNDARY ANIMAL DISEASES

Vaccine platform development efforts will consider the evaluation and discovery of novel negative markers to develop DIVA diagnostics as companion tests to current novel vaccine candidates. Novel nucleic acid and immunological-based technologies will also be developed for agent serotyping/subtyping, rapid vaccine matching, and monitoring evolutionary changes of TAD viruses in endemic settings. Next generation countermeasures should evaluate other areas including the characterization and validation of product claims relevant to current control strategies for commercially available and late-stage experimental vaccines, licensure of immunomodulators to induce early protection and complement next-generation vaccines, and the identification of cross-cutting vaccine platforms to produce a variety of vaccine products, including vaccine platforms suitable to meet response need. Primary sites of viral replication and the basic mechanisms responsible for systemic and persistent infections need to be evaluated and identified. The host responses to infection and the viral mechanisms leading to evasion of host immune responses need to be characterized to assess the mechanism mediating persistent viral infections. Pathway analysis is needed to characterize the mechanisms of induction and repression of innate defense mechanisms (e.g. Interferon). Genetic and immunological characterization of TAD infected and vaccinated animals will help identify genetic and biological determinants of protective immunity. For details, please refer to the solicitation details located at FedBizOpps website.

TTA-5 - RESEARCH AND DEVELOPMENT FELLOWSHIPS FOR TRANSBOUNDARY ANIMAL DISEASE PROFESSIONALS

Another key component of the NBAF research transition is the development of the next-generation of research scientists who are experienced in the planning and execution of research activities involving TADs in high and maximum containment. Agricultural biocontainment involves considerations of worker protection and public health, but also emphasizes a reduction of risk of environmental escape of study pathogens. In addition to differences in facility design and procedures associated with agricultural animal handling in these controlled environments, a different approach is required for risk assessment and management controls when accommodating agricultural pathogens, including TADs. The potential impacts of containment loss involve disruption of agricultural industry through clinical disease, production loss and disruption of trade. Fellowships and training courses will be developed to support the intellectual talent needed to meet the mission needs for NBAF. These programs will cultivate the next generation of scientists who will further contribute to the DHS S&T mission through innovation and research that contributes to the defense of U.S. agriculture. For details, please refer to the solicitation details located at FedBizOpps website.

Key Dates
Solicitation Open Date:
05/21/2015
Registration Deadline:
07/06/2015 04:30 PM ET
Submission Deadline:
07/06/2015 04:30 PM ET




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