Past Solicitations
BAA 14-003 Call 0003
DHS S&T CBD for Chemical and Biological R&D

This Call will consist of the solicitation, receipt, and evaluation of both White Papers and Full Proposals. Under this evaluation, Phase 1 will consist of the solicitation, receipt, and evaluation of the White Papers (using standardized DHS Chemical Biological Defense Division Project Proposal Form format) from potential performers. Entries in the various sections of the Project Proposal Forms (White Papers) should be concise and conform to the specified formatting and word count limitations. No formal transmittal letter is required for the Phase 1 responses. Once the white paper peer/scientific review process has been completed, offerors will be notified via e-mail, or in writing, whether as a result of its white paper submission, the offeror is encouraged or not encouraged to submit full proposals.

Topics

TTA-1 - High affinity products for select agent identification and neutralization

The goal of Technical Topic Area 1 is to develop new products for DHS to identify Ricin (RCA60, RCA120), Abrin, and C. botulinum toxins with high confidence. The heterogeneous nature of polyclonal sera can be problematic for the identification of specific biological toxins. New monoclonal antibodies, peptides, or small molecules are needed that act against defined toxins, resulting in increased specificity for toxin identification.

TTA-2 - Domain-specific products for select agent identification

The goal of Technical Topic Area 2 is to develop new products for DHS to identify individual domains of Ricin (RCA60, RCA120), Abrin, and C. botulinum (BoNT) toxins with high confidence and in a selective manner. Ricin, Abrin, and BoNT are highly distinct, with unique functional targets, mechanisms, cell types, and receptors. These toxins, including BoNT serotypes, have unique catalytic active sites, as well as distinct targeting and receptor-binding domains. Developing reagents against individual domains will allow the positive identification of specific toxins and serotypes with high specificity and selectivity.

TTA-3 - Sequence subtraction databases for viral metagenomics analyses

The goal of Technical Topic Area 3 is to develop sequence subtraction databases that will support the Department of Homeland Security capability to identify novel viruses that impact humans and agriculture. The databases will be used to remove host cell nucleic sequences from bioinformatic analyses to support viral discovery and in-depth characterization of viruses. The eukaryotic genome sequences of biological agent hosts, vectors, and reservoirs, as well as cell lines used for tissue culture will need to be generated in order to populate the databases. A large sequencing center will have the capacity to support high throughput sequencing in collaboration with the government to support closing this important gap. At a minimum, the resulting sequences should be high quality draft. All organisms and cell lines will be provided by the government for this effort, and the sequence data will be submitted to NCBI.

TTA-4 - Bacterial population genetics of select agent pathogens

The goal of Technical Topic Area 4 is to perform in-depth research on the bacterial populations of select agents where there are critical knowledge gaps. Successful prosecution of biocrimes is contingent upon a thorough understanding of the biology and structure of the bacterial population/species in question, as sample attribution is directly linked to the diversity of that population/species. Microbial forensic analyses need to be founded on an accurate understanding of existing levels of diversity, as well as the various mechanisms and patterns that drive genetic diversity accumulation. The Department of Homeland Security has a significant interest in understanding the population characteristics of C. botulinum and B. anthracis (the latter from North African and Middle Eastern regions only). All isolates and matrices (e.g. soils, source samples) positive for these bacterial agents and acquired for this BAA will be sent to the government as reference samples for addition to their repository collection.

Key Dates
Solicitation Open Date:
01/23/2015
White Paper Registration Deadline:
02/20/2015 03:00 PM ET
White Paper Submission Deadline:
02/20/2015 03:00 PM ET
Submission Deadline:
04/10/2015 03:00 PM ET


Amendments and Q&As
amendment icon Amendment # 2
Posted Date 1/30/15

( The date for submission of questions has been changed from January 30, 2015 3:00 EST to February 6, ...)
(Read Full)

The date for submission of questions has been changed from January 30, 2015 3:00 EST to February 6, 2015 3:00 EST. See attached Amendment Number 2.


amendment icon Amendment # 1
Posted Date 1/28/15
Amendment 1 for Call 3 evaluation criteria.



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