Chemical and Biological Research and Development CBD.07 Vaccines and Therapeutics: New, cost-effective, biological-based countermeasures for foreign animal disease (FAD) and zoonotic pathogens affecting major domestic livestock species. Specific areas of interest are cattle and swine product candidates based on molecular or recombinant vaccine platforms previously shown to be safe and effective against other infectious animal or human biodefense disease targets, panvalent vaccines and novel biological-derived broad spectrum antiviral agents with an established immune-based mechanism of action. (1) New, molecular-based or recombinant vaccine candidates that improve the onset of protective immunity and can differentiate infected from vaccinated animals. (2) Novel immunostimulants, adjuvants, or biological-based agents with an immune-based mechanism of action that can improve pathogen-specific vaccine efficacy and/or vaccine potency. (3) New molecular or recombinant-based vaccines that can increase spectrum of cross-protection against related strains. (4) New molecular or recombinant-based vaccines based on innovative state-of-the-art technologies (e.g., nanovaccines, VLPs). (5) New biological-based broad spectrum anti-viral therapeutics ( small molecule drugs excluded) that can be used in combination with pathogen-specific vaccines Department of Homeland Security (DHS) Science and Technology Directorate (S&T) Chemical and Biological Defense Division (CBD) BAA 14-003/Call 0012 Call 0012 Page 2 (6) Novel high throughput vaccine or biological delivery systems for livestock. NOTE: Influenza countermeasure proposals will not be considered.